Laboratory

The Laboratory of Tumor Immunology is one of the leading groups in the research of polymer-bound cancerostatics based on the HPMA copolymers. In this regard our laboratory tightly collaborates with the Laboratory of Biomedicinal Polymers at the Institute of Macromolecular Chemistry, CAS. v.v.i., and with clinicians at Faculty Hospital Motol.

Our laboratory takes an interdisciplinary approach, with an emphasis on quantitative and qualitative approaches drawn from multiple scientific disciplines, including molecular biology, cell biology and immunology.

By uncovering molecular and cellular processes, our scientists have established new paradigms in the cancer treatment, such as the decisive relationship between the structure and mode of action of polymeric drugs, and their ability to promote an effective immune response against cancer cells.

• The study of biological features of HPMA copolymer conjugates with respect for their molecular weight, structure and biologically active compound they bear (cytostatic drug, inhibitor of ABC transporter, protein)

• The testing of anticancer activity of HPMA copolymer conjugates containing cytostatic drug (doxorubicin, docetaxel and others) in the panel of selected tumor cell lines of both human and mouse origin in vitro and in several mouse tumor models in vivo

• The investigation of the immunocomplexes of IL-2 with different anti-IL-2 mAbs and the potential of these immunocomplexes to activate various populations of immunocompetent cells and modulate the immune responses